HEPATOPROTECTIVE EFFECT OF CAMEL MILK IN ANTITUBERCULOUS DRUGS INDUCED HEPATOTOXICITY IN MALE ALBINO RATS

Abstract

Background: Camel milk has been widely used as a dietry constituent in desert areas where camels are common. It has also been
in use to cure a number of commonly occurring diseases. Objective: To investigate the hepato protective effect of camel milk in
antituberculous drugs induced hepatotoxicity in rats. Methodology: This randomized control study was conducted on healthy
male albino rats. 24 male albino rats (200–250gms) were obtained from National Institute of Health, Islamabad and kept in animal
house of Pharmacology Department, Sheikh Zayed Medical College, Rahim Yar Khan. Rats were divided into 4-groups. Each
group consisted of 6 rats. Rats were given nutritionally standard diet and recommended dosage of antituberculous drugs along
with recommended quantity of camel milk. Data was entered and assessed by using SPSS version 17. Results: Hepatoprotective
effect of camel milk was analyzed by liver function parameters as serum aminotransferases, alkaline phosphatases and lactate
dehydrogenases. Data showed that antituberculous drugs given for 30 days developed severe liver damage. In biochemical study,
there was significant raise in serum diagnostic liver marker enzyme (ALT, AST, ALP and LDH) levels in ATT treated rats. Coadministration
of camel milk and antituberculous drugs led to significantly decreased enzyme levels. (P=0.01) Conclusion: This
study concluded that co-administration of camel milk can reduce the toxicity and damage of liver caused by antituberculous
drugs.